The usage of drugs which improve the erection is a quite delicate question. The most famous representative of this group of drugs is Viagra, but it has several disadvantages. From one side, the drug has a significant list of side effects and it has it`s safer substitutes. On the other hand, the high cost of Viagra is dictated solely by its fame and popularity in popular culture. One can buy Levitra online, which will be not only be more efficient, but also better in terms of price / quality ratio.
Active ingredient of the drug
Levitra is produced by the German company Bayer. It consists of the active ingredient vardenafil, which belongs to the class of phosphodiesterase-5 inhibitors (PDE-5). All drugs from this pharmaceutical group are the remedies to eliminate erectile dysfunction.
This Levitra is available in two forms: ordinary tablets in a protective coating and tablets soluble in the oral cavity (Levitra ODT). The last ones are much more expensive, but lead to a more rapid development of a positive effect.
Mechanism of action
The basis of the development of an erection is the relaxation of the musculature of the cavernous bodies of the penis and the dilatation of the vessels contained in it. These processes lead to the filling of the cavernous bodies with blood, which manifests itself in the form of an erection. During sexual arousal, the cells of the inner lining of the arteries of the penis begin to produce NO. Nitric oxide pulls the formation of guanylate cyclase and an increase in the formation of cGMP in the smoothes muscles of the cavernous bodies. The enzyme phosphodiesterase-5 cleaves cGMP, controlling the degree and duration of erection.
Since cGMP is itself responsible for the relaxation of smoothness of muscle cells, it is most advantageous to cause an increase in its concentration. It is not possible to do this by introducing NO: nitric oxide quickly decomposes, and the resulting cGMP rapidly decomposes under the action of PDE-5. Thus, it is much more effective to affect on the cGMP degrading enzyme.
Vardenafil, which is part of Levitra, blocks the activity of the PDE-5 enzyme. This leads to the accumulation of cGMP, increased relaxation of the smooth muscles of the penis, blood flow and the development of erection.
There are more than 10 types of phosphodiesterase. Its fifth type (PDE-5) participates in the processes of sexual arousal, while others take part in the regulation of vascular tone of other organs and tissues, the regulation of color perception and other processes. The main disadvantage of Viagra is the relatively low selectivity in relation to the suppression of PDE activity. This leads to the main side effects of the drug in the form of a drop in blood pressure, facial flushing, nasal congestion, and visual impairment.
Levitra interacts primarily with PDE-5. It is 15 to 1000 times more active with respect to this form of the enzyme than with other phosphodiesterases.
The active ingredient vardenafil is indicated in cases where there are problems with erection. The drug allows you to cope with various age and organic problems, as well as with psychogenic erectile dysfunction.
Levitra can not be used in the following situations:
- Intolerance to the drug and the active substance, incl. allergy;
- Taking nitrosovasodilators (nitroglycerin, Isoket, Nitrospray, etc.);
- Acceptance of CYP3A4 inhibitors (antifungal ketoconazole and itraconazole, antibiotics erythromycin and clarithromycin, antiviral ritonavir and indavir);
- The presence of diseases of the cardiovascular system (angina, heart failure).
Relative contraindications include:
- Any deformation of the penis;
- Tendency to priapism (uncontrolled erection without sexual arousal) of any origin;
- Increased risk of bleeding;
- Exacerbation of gastric ulcer, duodenal ulcer.
For some conditions, there are no information regarding the usage of Levitra. In this regard, it does not recommended its use in order to avoid unexpected reactions when patient has:
- Liver failure;
- Severe renal failure;
- Blood pressure less than 90/60 mm Hg;
- Myocardial infarction or stroke, suffered in the last six months;
- Diseases of the retina of any origin.
Among the undesirable effects, Levitra is mainly dominated by the same side affects as Viagra, but they are being faced 1.5 – 2 times rare:
- Pain in the head;
- Feeling dizzy;
- Redness of the face;
- Nasal congestion;
- Digestive upset.
Less than 1% of men while taking Levitra can face with:
- Allergic reactions;
- Inflammation of the conjunctiva;
- Sleep disorder;
- Impaired skin sensitivity;
- Changing color perception;
- Noise in ears;
- Violation of myocardial blood supply;
- Drop in blood pressure;
- shortness of breath;
- Temporary deterioration of liver function;
- Pain in the back, muscles;
Interaction with other drugs
The simultaneous use of Levitra with erythromycin, ketoconazole, itraconazole, indinavir, ritonavir leads to an increase in the concentration of both drugs, the deterioration of their metabolism and excretion, the hepatotoxic effect and the development of side effects.
With the simultaneous use of Levitra and any nitrates, alpha-blockers increases the risk of a sharp drop in blood pressure.
Instructions for use
If you got cheap Levitra online and you have already purchased it, you should reed it`s main rules.
Coated tablets should be taken orally, approximately 30-60 minutes before the intended sexual intercourse. One can use the drug even 4-5 hours before intimate intimacy.
Tablets can not be chewed, crushed, one need to drink a moderate amount of water. The medicine is taken without being tied to food intake.
Levitra Odt is a tablet, dispersible (soluble) in the oral cavity. One tablet is placed in the oral cavity, where it dissolves quickly. After its dissolution a small amount of water should be drunk.
Levitra can be taken no more than 1 time in 24 hours. The maximum daily dose is 20 mg, the minimum is 5 mg. In elderly and senile age, renal or hepatic insufficiency, dosage adjustment is not required.
Analogs and Substitutes
If the drug does not suits the patient, then on can try to buy analogues of Levitra. With Vardenafil as an active ingredient, Levitra and Vardenafil are produced directly. All other drugs that improve erectile function will contain other types of PDE-5 inhibitors.
Viagra and its generics
Viagra contains the active substance sildenafil. The drug is less selective in terms of inhibition of phosphodiesterase, which leads to more frequent cases of undesirable reactions. Brand blue pills will be quite expensive, therefore it is better to choose any of the generics: Viasan, Vivaira, Dynamico, Maksigra, Sealeks, Sildenafil, Silden, etc.
All these drugs can be taken as a cheaper Levitra, but their quality will be somewhat lower.
Cialis and other drugs with tadalafil
The active substance tadalafil inhibits PDE-5 even more selectively in comparison with other forms of this enzyme. The drug rarely causes side effects, highly effective, but also have to pay for the quality. Tadalafil contains the following medications: Cialis (brand), Dynamic, Sitara, Tadalafil.
Can I buy without a prescription
Officially, all phosphodiesterase inhibitors are being sold by prescription only. However, not all pharmacies require the presentation of a medical form with a seal. Another common question: “Where can I buy cheap Levitra online?”. The drug can be found on the portal online pharmacies, and on sites specializing in the sale of drugs for male potency.