Drugs for increasing potency have been used by men all around the world for several decades. The most famous representative of this class of drugs is Viagra. However, popular blue pills have their drawbacks in the form of high price and a number of side effects. If you buy Nizagara online, then you can save significantly, without losing a quality.
Main active ingredient
The main active ingredient in Combitic Global’s Nizagara product is sildenafil (25 or 100 mg tablets), which is also included in Viagra.
In addition to sildenafil, this Nizagara contains L-arginine (200 mg), ginseng (100 mg), vitamins B6 and B12. However, there exists other forms of the drug with pure sildenafil, without any auxiliary components.
Principle of action
The active ingredient of Nizagara inhibits the activity of the enzyme phosphodiestarase-5 (PDE-5). This enzyme destroys cGMP, which causes vasodilation of the cavernous bodies of the penis, blood flow and the development of erection. Due to the suppression of PDE-5 activity, sildenafil contributes to the accumulation of cGMP and enhance erection.
The cGMP itself is produced by the vascular endothelium of the penis under the action of nitric oxide, which is produced during sexual arousal.
Sildenafil is not sufficiently selective in terms of inhibition of PDE-5, which causes the development of side effects. Other types of phosphodiesterase are located in skeletal muscle, retina, and vessels of the whole body. The main active ingredient of Nizagara is only 10 times more strongly bound to PDE-5 than to PDE-6 and 80 times stronger than PDE-1. This leads to the development of such undesirable reactions on the drug, such as facial flushing and nasal congestion, changes in color perception.
Auxiliary components do not have a special positive effect, but they also do not cause side effects. L-arginine is one of the amino acids, which is necessary for the formation of sperm and does not directly affect on the erection. Ginseng is a plant which increases physical endurance and overall body resistance only with daily long-term intake. B vitamins are involved in the blood, the metabolic processes of the central nervous system, but really effective only during immunodeficient states.
Nizagara can be used in the following situations:
• Erectile dysfunction of organic or mental origin;
• Increased pressure in the pulmonary circulation.
The absolute contraindications for the usage are:
• Individual intolerance to Nizagara;
• intolerance to any of the components of the drug;
• Taking nitrosovasodilators (nitroglycerin, isosorbide dinitrate, Isoket, Nitrospray, Nitrogranulong, etc.).
Also medication for eliminating erectile dysfunction should not be used in cases of:
- The risk of priapism development (uncontrolled pathological erection) in case of oncological diseases of the blood, sickle cell anemia, etc.;
- Propensity to develop bleeding;
- Peptic ulcer of the stomach or duodenum in the acute stage;
- Retinal lesions;
- Abnormal liver function for any reason;
- Cirrhosis of the liver;
- Impaired severe renal function;
- High blood pressure (over 170/110 mm Hg);
- Low blood pressure (less than 90/50 mm Hg);
- Heart attack, stroke, intracranial hemorrhage, suffered in the last 6 months;
- Heart failure;
- Unstable angina pectoris (first developed or progressive);
- Taking drugs that are metabolized with the participation of cytochrome P450.
More than 2% of men taking drugs with sildenafil in the composition face with the following adverse of reactions (from most common to least):
- Head pain;
- Rush of blood to the face, redness of the cheeks;
- Disruption of the digestive system;
- Abnormal color perception, hypersensitivity to light, sensation of veil before eyes;
- Deterioration of nasal breathing;
- The appearance of infectious diseases of the urinary system;
- Allergic reactions.
Less than 2 out of 100 men develop:
- Migraine headaches;
- Retinal hemorrhage;
- Impaired blood supply to the myocardium (angina, heart attack);
- Heart rhythm disorders;
- Violation of cerebral circulation;
- Asthma attacks;
- Bleeding in the gastrointestinal tract;
- Sprains and tendon ruptures;
- All sorts of dermatitis.
Instructions for use
If you decide to purchase cheap Nizagru online for use, then first read the instructions.
The drug should be taken orally for 2-3 hours before the alleged sexual intercourse. Nisagara tablets should not be chewed or crushed in any way. For a more comfortable use they should be washed down with a big amount of water.
To reduce the risk of side effects, it is undesirable to drink more than 100 mg of Nizagara per day.
Analogs and Substitutes
If cheap Nizagra does not suits you in its effectiveness, contraindications or side effects, you should pay attention to its analogues.
Sildenafil and Viagra
The main active ingredient sildenafil, is also a composition in a number of other drugs: Viagra, Vivaira, Dynamico, Maksigra, Sildenafil-C3 and others. The main difference between these drugs is that they do not contain auxiliary components and only PDE-5 inhibitor is included in them. These drugs are usually more expensive. In fact, you can buy generic Nizagara, Sildenafil-C3, or anything else and not even notice any difference.
Drugs with vardenafil
Vardenafil (Levitra) is more selective in suppressing PDE-5 activity. It is less likely to cause side effects, but it is more expensive. Levitra also contains nothing but an erection regulator.
Among all the PDE-5 inhibitors, tadalafil is the most selective. It almost never causes side effects unlike sildenafil. The drug is effective not only for the treatment of erectile dysfunction, but also for benign prostatic hyperplasia.
Can I buy without a prescription
Nizagara is being actively sold in Western countries. If you ask the question “Where can I buy cheap Nizagara online?”, then the best thing is to start your search from specialized sites and portals. This medicine can be easily purchased online and for this, most likely, you will not even need a prescription from the doctor.