Use Of Cheap Levitra

The usage of drugs which improve the erection is a quite delicate question. The most famous representative of this group of drugs is Viagra, but it has several disadvantages. From one side, the drug has a significant list of side effects and it has it`s safer substitutes. On the other hand, the high cost of Viagra is dictated solely by its fame and popularity in popular culture. One can buy Levitra online, which will be not only be more efficient, but also better in terms of price / quality ratio.

Active ingredient of the drug

Levitra is produced by the German company Bayer. It consists of the active ingredient vardenafil, which belongs to the class of phosphodiesterase-5 inhibitors (PDE-5). All drugs from this pharmaceutical group are the remedies to eliminate erectile dysfunction.
This Levitra is available in two forms: ordinary tablets in a protective coating and tablets soluble in the oral cavity (Levitra ODT). The last ones are much more expensive, but lead to a more rapid development of a positive effect.

Mechanism of action

The basis of the development of an erection is the relaxation of the musculature of the cavernous bodies of the penis and the dilatation of the vessels contained in it. These processes lead to the filling of the cavernous bodies with blood, which manifests itself in the form of an erection. During sexual arousal, the cells of the inner lining of the arteries of the penis begin to produce NO. Nitric oxide pulls the formation of guanylate cyclase and an increase in the formation of cGMP in the smoothes muscles of the cavernous bodies. The enzyme phosphodiesterase-5 cleaves cGMP, controlling the degree and duration of erection.
Since cGMP is itself responsible for the relaxation of smoothness of muscle cells, it is most advantageous to cause an increase in its concentration. It is not possible to do this by introducing NO: nitric oxide quickly decomposes, and the resulting cGMP rapidly decomposes under the action of PDE-5. Thus, it is much more effective to affect on the cGMP degrading enzyme.
Vardenafil, which is part of Levitra, blocks the activity of the PDE-5 enzyme. This leads to the accumulation of cGMP, increased relaxation of the smooth muscles of the penis, blood flow and the development of erection.
There are more than 10 types of phosphodiesterase. Its fifth type (PDE-5) participates in the processes of sexual arousal, while others take part in the regulation of vascular tone of other organs and tissues, the regulation of color perception and other processes. The main disadvantage of Viagra is the relatively low selectivity in relation to the suppression of PDE activity. This leads to the main side effects of the drug in the form of a drop in blood pressure, facial flushing, nasal congestion, and visual impairment.
Levitra interacts primarily with PDE-5. It is 15 to 1000 times more active with respect to this form of the enzyme than with other phosphodiesterases.

Indications

The active ingredient vardenafil is indicated in cases where there are problems with erection. The drug allows you to cope with various age and organic problems, as well as with psychogenic erectile dysfunction.

Contraindications

Levitra can not be used in the following situations:

  • Intolerance to the drug and the active substance, incl. allergy;
  • Taking nitrosovasodilators (nitroglycerin, Isoket, Nitrospray, etc.);
  • Acceptance of CYP3A4 inhibitors (antifungal ketoconazole and itraconazole, antibiotics erythromycin and clarithromycin, antiviral ritonavir and indavir);
  • The presence of diseases of the cardiovascular system (angina, heart failure).

Relative contraindications include:

  • Any deformation of the penis;
  • Tendency to priapism (uncontrolled erection without sexual arousal) of any origin;
  • Increased risk of bleeding;
  • Exacerbation of gastric ulcer, duodenal ulcer.

For some conditions, there are no information regarding the usage of Levitra. In this regard, it does not recommended its use in order to avoid unexpected reactions when patient has:

  • Liver failure;
  • Severe renal failure;
  • Blood pressure less than 90/60 mm Hg;
  • Myocardial infarction or stroke, suffered in the last six months;
  • Stenocardia;
  • Diseases of the retina of any origin.

Side effects

Among the undesirable effects, Levitra is mainly dominated by the same side affects as Viagra, but they are being faced 1.5 – 2 times rare:

  • Pain in the head;
  • Feeling dizzy;
  • Redness of the face;
  • Nasal congestion;
  • Digestive upset.

Less than 1% of men while taking Levitra can face with:

  • Allergic reactions;
  • Inflammation of the conjunctiva;
  • Sleep disorder;
  • Drowsiness;
  • Impaired skin sensitivity;
  • Changing color perception;
  • Noise in ears;
  • Cardiopalmus;
  • Violation of myocardial blood supply;
  • Drop in blood pressure;
  • shortness of breath;
  • Temporary deterioration of liver function;
  • Pain in the back, muscles;
  • Priapism.

Interaction with other drugs

The simultaneous use of Levitra with erythromycin, ketoconazole, itraconazole, indinavir, ritonavir leads to an increase in the concentration of both drugs, the deterioration of their metabolism and excretion, the hepatotoxic effect and the development of side effects.
With the simultaneous use of Levitra and any nitrates, alpha-blockers increases the risk of a sharp drop in blood pressure.
Instructions for use
If you got cheap Levitra online and you have already purchased it, you should reed it`s main rules.
Coated tablets should be taken orally, approximately 30-60 minutes before the intended sexual intercourse. One can use the drug even 4-5 hours before intimate intimacy.
Tablets can not be chewed, crushed, one need to drink a moderate amount of water. The medicine is taken without being tied to food intake.
Levitra Odt is a tablet, dispersible (soluble) in the oral cavity. One tablet is placed in the oral cavity, where it dissolves quickly. After its dissolution a small amount of water should be drunk.
Levitra can be taken no more than 1 time in 24 hours. The maximum daily dose is 20 mg, the minimum is 5 mg. In elderly and senile age, renal or hepatic insufficiency, dosage adjustment is not required.

Analogs and Substitutes

If the drug does not suits the patient, then on can try to buy analogues of Levitra. With Vardenafil as an active ingredient, Levitra and Vardenafil are produced directly. All other drugs that improve erectile function will contain other types of PDE-5 inhibitors.

Viagra and its generics

Viagra contains the active substance sildenafil. The drug is less selective in terms of inhibition of phosphodiesterase, which leads to more frequent cases of undesirable reactions. Brand blue pills will be quite expensive, therefore it is better to choose any of the generics: Viasan, Vivaira, Dynamico, Maksigra, Sealeks, Sildenafil, Silden, etc.
All these drugs can be taken as a cheaper Levitra, but their quality will be somewhat lower.

Cialis and other drugs with tadalafil

The active substance tadalafil inhibits PDE-5 even more selectively in comparison with other forms of this enzyme. The drug rarely causes side effects, highly effective, but also have to pay for the quality. Tadalafil contains the following medications: Cialis (brand), Dynamic, Sitara, Tadalafil.

Can I buy without a prescription

Officially, all phosphodiesterase inhibitors are being sold by prescription only. However, not all pharmacies require the presentation of a medical form with a seal. Another common question: “Where can I buy cheap Levitra online?”. The drug can be found on the portal online pharmacies, and on sites specializing in the sale of drugs for male potency.

Purchase Cheap Nizagara – Instructions

Drugs for increasing potency have been used by men all around the world for several decades. The most famous representative of this class of drugs is Viagra. However, popular blue pills have their drawbacks in the form of high price and a number of side effects. If you buy Nizagara online, then you can save significantly, without losing a quality.

Main active ingredient

The main active ingredient in Combitic Global’s Nizagara product is sildenafil (25 or 100 mg tablets), which is also included in Viagra.
In addition to sildenafil, this Nizagara contains L-arginine (200 mg), ginseng (100 mg), vitamins B6 and B12. However, there exists other forms of the drug with pure sildenafil, without any auxiliary components.

Principle of action

The active ingredient of Nizagara inhibits the activity of the enzyme phosphodiestarase-5 (PDE-5). This enzyme destroys cGMP, which causes vasodilation of the cavernous bodies of the penis, blood flow and the development of erection. Due to the suppression of PDE-5 activity, sildenafil contributes to the accumulation of cGMP and enhance erection.
The cGMP itself is produced by the vascular endothelium of the penis under the action of nitric oxide, which is produced during sexual arousal.
Sildenafil is not sufficiently selective in terms of inhibition of PDE-5, which causes the development of side effects. Other types of phosphodiesterase are located in skeletal muscle, retina, and vessels of the whole body. The main active ingredient of Nizagara is only 10 times more strongly bound to PDE-5 than to PDE-6 and 80 times stronger than PDE-1. This leads to the development of such undesirable reactions on the drug, such as facial flushing and nasal congestion, changes in color perception.
Auxiliary components do not have a special positive effect, but they also do not cause side effects. L-arginine is one of the amino acids, which is necessary for the formation of sperm and does not directly affect on the erection. Ginseng is a plant which increases physical endurance and overall body resistance only with daily long-term intake. B vitamins are involved in the blood, the metabolic processes of the central nervous system, but really effective only during immunodeficient states.

Indications

Nizagara can be used in the following situations:
• Erectile dysfunction of organic or mental origin;
• Increased pressure in the pulmonary circulation.
Contraindications
The absolute contraindications for the usage are:
• Individual intolerance to Nizagara;
• intolerance to any of the components of the drug;
• Taking nitrosovasodilators (nitroglycerin, isosorbide dinitrate, Isoket, Nitrospray, Nitrogranulong, etc.).
Also medication for eliminating erectile dysfunction should not be used in cases of:
Side effects

  • The risk of priapism development (uncontrolled pathological erection) in case of oncological diseases of the blood, sickle cell anemia, etc.;
  • Propensity to develop bleeding;
  • Peptic ulcer of the stomach or duodenum in the acute stage;
  • Retinal lesions;
  • Abnormal liver function for any reason;
  • Cirrhosis of the liver;
  • Impaired severe renal function;
  • High blood pressure (over 170/110 mm Hg);
  • Low blood pressure (less than 90/50 mm Hg);
  • Heart attack, stroke, intracranial hemorrhage, suffered in the last 6 months;
  • Heart failure;
  • Unstable angina pectoris (first developed or progressive);
  • Taking drugs that are metabolized with the participation of cytochrome P450.

More than 2% of men taking drugs with sildenafil in the composition face with the following adverse of reactions (from most common to least):

  • Head pain;
  • Dizziness;
  • Rush of blood to the face, redness of the cheeks;
  • Disruption of the digestive system;
  • Abnormal color perception, hypersensitivity to light, sensation of veil before eyes;
  • Deterioration of nasal breathing;
  • The appearance of infectious diseases of the urinary system;
  • Allergic reactions.

Less than 2 out of 100 men develop:

  • Migraine headaches;
  • Fainting;
  • Retinal hemorrhage;
  • Impaired blood supply to the myocardium (angina, heart attack);
  • Heart rhythm disorders;
  • Violation of cerebral circulation;
  • Asthma attacks;
  • Bleeding in the gastrointestinal tract;
  • Sprains and tendon ruptures;
  • All sorts of dermatitis.

Instructions for use

If you decide to purchase cheap Nizagru online for use, then first read the instructions.
The drug should be taken orally for 2-3 hours before the alleged sexual intercourse. Nisagara tablets should not be chewed or crushed in any way. For a more comfortable use they should be washed down with a big amount of water.
To reduce the risk of side effects, it is undesirable to drink more than 100 mg of Nizagara per day.

Analogs and Substitutes

If cheap Nizagra does not suits you in its effectiveness, contraindications or side effects, you should pay attention to its analogues.

Sildenafil and Viagra

The main active ingredient sildenafil, is also a composition in a number of other drugs: Viagra, Vivaira, Dynamico, Maksigra, Sildenafil-C3 and others. The main difference between these drugs is that they do not contain auxiliary components and only PDE-5 inhibitor is included in them. These drugs are usually more expensive. In fact, you can buy generic Nizagara, Sildenafil-C3, or anything else and not even notice any difference.

Drugs with vardenafil

Vardenafil (Levitra) is more selective in suppressing PDE-5 activity. It is less likely to cause side effects, but it is more expensive. Levitra also contains nothing but an erection regulator.

Tadalafil

Among all the PDE-5 inhibitors, tadalafil is the most selective. It almost never causes side effects unlike sildenafil. The drug is effective not only for the treatment of erectile dysfunction, but also for benign prostatic hyperplasia.

Can I buy without a prescription

Nizagara is being actively sold in Western countries. If you ask the question “Where can I buy cheap Nizagara online?”, then the best thing is to start your search from specialized sites and portals. This medicine can be easily purchased online and for this, most likely, you will not even need a prescription from the doctor.